Effect of Anesthetic Agents on Optic Nerve Sheath Diameter

Effect of Anesthetic Agents (Propofol, Sevoflurane) on Optic Nerve Sheath Diameter(ONSD) in Patients Undergoing Robot-assisted Laparoscopic Gynecology Surgery

The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.

Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases.

Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.

Inclusion Criteria:

• female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy

Exclusion Criteria:

• history of brain hemorrhage or brain infarction
• liver disease or end stage renal disease
• glaucoma or any signs of increased intraocular pressure
• combined wtih other types of operation
• patient refusal
• weight less than 40 kg or over 100 kg