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| Name | Class |
|---|---|
| Kocatepe University | OTHER |
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This study is designed to examine the short-term and long-term effects of blood flow restriction exercise training on physiological and biochemical markers in individuals who are new to strength training and in experienced athletes training at different load levels. This exercise method involves placing a special inflatable cuff around the upper part of the thigh. The cuff partially limits blood flow to the area, which helps the muscles work more effectively during exercise. The cuff will be applied only to the individual's dominant leg (the leg you use more often in daily activities), but all exercises will be performed using both legs. The exercise program will last for a total of six weeks and will be carried out twice per week. The pressure applied by the cuff will be individually adjusted based on each participant's physical characteristics to ensure safety and comfort. The study will include a total of 30 healthy participants aged between 18 and 40 years. Participants will be divided into two groups: individuals who have recently started strength training and experienced athletes with different levels of training experience.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Novice Training Group | This group consists of healthy individuals who are new to strength training. Participants in this group will perform low-intensity resistance exercises with blood flow restriction applied to the proximal thigh using an inflatable cuff. |
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| Experienced Athletes Group | This group includes healthy experienced athletes from different sports disciplines and training load levels. Participants will perform the same low-intensity blood flow restriction exercise protocol applied to the proximal thigh using an inflatable cuff. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood Flow Restriction Training | Other | Adaptation to blood flow restriction exercise training and the individually tailored occlusion pressure will be determined during the initial sessions. Occlusion pressure will be assessed while the participant is in a supine position by inflating a pneumatic cuff placed on the thigh until the tibial artery pulse is no longer detectable, which will be confirmed using a handheld Doppler device. To ensure safe adaptation to the training protocol, the pressure applied during the first two training sessions will be set below the individually determined target pressure. The full target occlusion pressure will be implemented starting from the third training session. For example, if the target pressure is determined as 300 mmHg, exercises will be performed at 200 mmHg during the first session and 250 mmHg during the second session. Blood flow restriction training principles will be applied during exercise loading. Four different types of exercises will be set up in four sets. |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle Thickness | Baseline and after 6 weeks of training | |
| Blood Biomarkers | Oxidative Stress Markers Growth Factor Levels Muscle Damage Markers | Blood samples will be collected at three time points: before and immediately after the third training session to assess acute responses, and at the end of the 6-week training period to assess long-term effects. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of healthy adults aged 18-40 years, including individuals who are new to strength training and experienced athletes from different sports disciplines with varying training load levels.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dilara KARA | Contact | +90 530 237 1991 | dilaradonder@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Afyonkarahisar Health Sciences University | Recruiting | Afyonkarahisar | Merkez | 03030 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28481416 | Result | Nielsen JL, Aagaard P, Prokhorova TA, Nygaard T, Bech RD, Suetta C, Frandsen U. Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage. J Physiol. 2017 Jul 15;595(14):4857-4873. doi: 10.1113/JP273907. Epub 2017 Jun 23. | |
| 29448855 | Result |
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| ID | Term |
|---|---|
| D000090003 | Blood Flow Restriction Therapy |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Centner C, Zdzieblik D, Dressler P, Fink B, Gollhofer A, Konig D. Acute effects of blood flow restriction on exercise-induced free radical production in young and healthy subjects. Free Radic Res. 2018 Apr;52(4):446-454. doi: 10.1080/10715762.2018.1440293. Epub 2018 Mar 15. |
| 28805932 | Result | Franchi MV, Longo S, Mallinson J, Quinlan JI, Taylor T, Greenhaff PL, Narici MV. Muscle thickness correlates to muscle cross-sectional area in the assessment of strength training-induced hypertrophy. Scand J Med Sci Sports. 2018 Mar;28(3):846-853. doi: 10.1111/sms.12961. Epub 2017 Sep 21. |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |