Resistance Training With Blood Flow Restriction | NCT05863039

Studies
Resistance Training With Blood Flow Restriction

NCT05863039

Sponsor

University of Oklahoma

Status

Completed

Last Update Posted

May 1, 2026Actual

Enrollment

8Actual

Phase

Not Applicable

Conditions

Healthy

Interventions

Blood flow restriction
Regular training type 1
Regular training type 2

Countries

United States

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Apr 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Nov 1, 2022Actual

Primary Completion Date

May 31, 2025Actual

Completion Date

Apr 27, 2026Actual

First Submitted Date

Apr 17, 2023

First Submission Date that Met QC Criteria

May 8, 2023

First Posted Date

May 17, 2023Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Apr 27, 2026

Last Update Posted Date

May 1, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.

Detailed Description

The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

8Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Group 1	Experimental	Strength training associated with blood flow restriction	Other: Blood flow restriction
Group 2	Experimental	Conventional strength training using high loads	Other: Regular training type 1
Group 3	Experimental	Conventional strength training using low loads	Other: Regular training type 2

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Blood flow restriction	Other	Strength training of the lower leg muscles using blood flow restriction	Group 1

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Force	Force of the lower leg muscles using a custom made ergometer	10 sessions (up to 6 weeks)

Secondary Outcomes

Measure	Description	Time Frame
Body composition	dual x-ray absorptiometry (DEXA) will be used to assess body composition	Start and end of the protocol

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Exclusion Criteria:

presence of neurological diseases,
presence of metal implants or joint replacement
any restriction to perform physical activity
pregnancy

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

50 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Hugo Pereira, PhD	University of Oklahoma	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
University of Oklahoma		Norman	Oklahoma	73071	United States

IPD Sharing Statement Module

Plan to Share IPD

Yes

Description

deidentified information can be shared according to instructions of the local institutional review board that reviewed the study

Types

Study Protocol

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D000090003	Blood Flow Restriction Therapy

Ancestor Terms

ID	Term
D005081	Exercise Therapy
D012046	Rehabilitation
D000359	Aftercare
D003266	Continuity of Patient Care

Browse Leaves

Not provided

Browse Branches

Not provided