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A key faculty at our college who was helping with the project left the college.
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The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.
Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last ~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eccentric only training | Active Comparator | This is the experimental control; where this group will be used as the standard active comparison condition. |
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| Eccentric plus blood-flow restriction | Experimental | This is the experimental condition involving the eccentric resistance training with blood flow restriction. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | The interventions are a form or exercise, specifically resistance exercise. |
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| Measure | Description | Time Frame |
|---|---|---|
| Eccentron maximal muscle strength | Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer. | 7 weeks |
| Local muscle hypertrophy | Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA). | 7 weeks |
| Muscle mass | dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass. | 7 weeks |
| Muscle function | Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time. | 7 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle soreness | local muscle soreness will be assessed throughout the duration of the intervention period using a Wagner force algometer. | 7 weeks |
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Inclusion Criteria:
Exclusion Criteria:
For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).
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| Name | Affiliation | Role |
|---|---|---|
| Brennan J Thompson, PhD | Utah State Univeristy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Utah State Universtiy | Logan | Utah | 84322 | United States |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Two group, randomized parallel group design.
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The person assessing the outcome measures will be blinded to the group designation of the subjects.
| Eccentric plus blood-flow restriction | Other | Eccentric plus blood-flow restriction |
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