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To establish evidence that cold ischemia, achieved through the use of ice slush, can improve the recovery from ischemia on the operated kidney in patients undergoing robot-assisted partial nephrectomy.
Randomly dividing the study cohorts into two groups. One group undergoing cold ischemia partial nephrectomy and the other undergoing warm ischemia partial nephrectomy. Comparing the short-term renal function recovery between the two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cold ischemia | Experimental | During the surgical procedure, employing ice to achieve local hypothermia in the kidneys. |
|
| Warm ischemia | Active Comparator | Not applying local hypothermia to the kidneys during the surgical procedure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cold ischemia robot-assisted partial nephrectomy | Procedure | During the surgical procedure, employing ice to achieve local hypothermia in the kidneys. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recovery from ischemia | (%GFR saved)/(%parenchymal mass preserved) | 1-12 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| surgical duration | The duration of the surgery | Intraoperative |
| surgical complications | Intraoperative and postoperative complication incidence rate |
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Inclusion Criteria:
- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fangjian Zhou, professor | Contact | 020-87343865 | zhoufj@sysucc.org.cn |
| Name | Affiliation | Role |
|---|---|---|
| Fangjian Zhou, professor | Sun Yat-sen University Cancer Center (SYSUCC) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center； | Recruiting | Guangzhou | Guangdong | 510000 | China |
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| ID | Term |
|---|---|
| D002292 | Carcinoma, Renal Cell |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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Randomly dividing the study cohorts into two groups. One group undergoing cold ischemia robot-assisted partial nephrectomy，while the other group undergoing warm ischemia robot-assisted partial nephrectomy
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| Warm ischemia robot-assisted partial nephrectomy | Procedure | Not applying local hypothermia to the kidneys during the surgical procedure |
|
| 1-12 months after surgery |
| The extent of decline in the long-term GFR (month13-24) on the operated kidney compared to the new baseline GFR(months 1-12). | Postoperative short-term GFR(months 1-12) minus long-term GFR(month13-24) | up to 2 years after surgery |
| D009369 | Neoplasms |
| D007680 | Kidney Neoplasms |
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |