Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

Clinical and Biochemical Evaluation of Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management of Stage II Grade A Periodontitis: A Randomized Controlled Clinical Trial

melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis

Inclusion Criteria:

- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification

• Minimum of two non-adjacent periodontal pockets <5 mm in different quadrants

• Systemically healthy individuals willing to participate and comply with follow-up visits

• Radiographic bone loss (ranged from is 10-20% mostly horizontal

Exclusion Criteria:

History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis)

• Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months

• Smoking or tobacco use

• Pregnancy or lactation

• Allergy to melatonin or related compounds

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