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melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Scaling and Root Planning only | No Intervention | Mechanical removal of supra- and subgingival plaque and calculus using ultrasonic and hand instruments. | |
| Injectable Platelet-Rich Fibrin (i-PRF) | Placebo Comparator | local application of injectable platelet-rich fibrin (i-PRF) into periodontal pockets. |
|
| scaling and Root Planing plus Melatonin-Loaded Injectable Platelet-Rich Fibrin | Experimental | patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Melatonin-Loaded Injectable Platelet-Rich Fibrin | Drug | patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level (CAL) | 6 months |
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Inclusion Criteria:
- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification
• Minimum of two non-adjacent periodontal pockets <5 mm in different quadrants
• Systemically healthy individuals willing to participate and comply with follow-up visits
• Radiographic bone loss (ranged from is 10-20% mostly horizontal
Exclusion Criteria:
History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis)
• Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months
• Smoking or tobacco use
• Pregnancy or lactation
• Allergy to melatonin or related compounds
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dental Medicine for girls Al-Azhar University | New Cairo | Egypt |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| C043309 | proliferation regulatory factors, human urine |
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| injectible platelet rich fibrin (i-PRF ) | Biological | patients will be included in this group receiving (SRP) with local application of i-PRF |
|