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| ID | Type | Description | Link |
|---|---|---|---|
| Aadj@azhar.edu.eg | Registry Identifier | ISSN 2682-2822 |
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This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month. The periodontal parameters were recorded at baseline, 1week, 1and 3 months.Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of receptor activator nuclear K ligand (RANKL) was carried out by using Enzyme-Linked Immunosorbent Assay (ELISA) at baseline, 1week, 1 and 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gp I(Melatonin gp) | Active Comparator | Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. |
|
| Gp II(placebo gp) | Placebo Comparator | Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Melatonin2%gel | Drug | Intra-pocket application of 2% Melatonin gel |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of Melatonin gel by determine the change on measurements of clinical parameter in chronic periodontitis. | positive change in clinical parameter by millimeter | 2 weeks |
| EFFICACY of Melatonin Gel by positive change measurements of clinical parameter "pocket depth ,attachment loss" | positive change in clinical parameter by millimeter | 1: 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| EFFICACY of Melatonin Gel by positive change on concentration level of Receptor activator nuclear K ligand ( RANKL) in Gingival crevicular fluid (GCF) | microbiology analysis by Receptor activator nuclear K ligand(ELISA ) by picogram | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| pre-opertive measurements of clinical parameter in chronic periodontitis | negative result in clinical parameter measurments by millimeter | at beginning of trial |
Inclusion Criteria:
clinical diagnosed with chronic periodontitis , must be able to maintan good oral hygiene
Exclusion Criteria:
Diabetic mellitus immunsuppressive medication
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alazhar university ,faculty of Dental Medicine | Asyut | 0000 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | kotb, shaymaa Hussein Rafat |
| Label | URL |
|---|---|
| shaymaa+kotb@orcid | View source |
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yes ,no problem to share study result
any time .It is already published
DOI: 10.21608/aadj.2022.267325
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jan 1, 2020 | Mar 3, 2023 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| C536059 | Osteopetrosis, mild autosomal recessive form |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month.
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| PLACEBO | Drug | placebo intra-pocket application |
|
| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |