Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex on cognitive function and dual-task performance in individuals with Parkinson's disease. Participants completed ten rTMS sessions over two weeks or received sham stimulation. Cognitive status was assessed using the Montreal Cognitive Assessment, and mobility was evaluated through single-task and multiple dual-task Timed Up and Go tests. The study examined whether rTMS could enhance cognitive abilities and improve motor-cognitive performance, which are commonly impaired in Parkinson's disease and contribute to reduced functional independence. Findings indicated that rTMS led to improvements in cognition, single-task mobility, and complex dual-task performance. The intervention was well tolerated, and no adverse events related to the stimulation intensity were reported.
Parkinson's disease often leads to declines in cognition, gait performance, and the ability to manage simultaneous cognitive-motor demands. These difficulties contribute to mobility limitations, fall risk, and loss of independence in older adults. This randomized controlled study investigates whether repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex can enhance cognitive function and improve single- and dual-task mobility performance in individuals with Parkinson's disease. Participants complete a two-week intervention consisting of active or sham stimulation. Standardized cognitive and functional mobility assessments are administered before and after the intervention to determine the extent of change associated with rTMS. The study is designed to provide preliminary evidence on whether neuromodulation of an executive-control region can support functional motor-cognitive interactions in this population.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active rTMS Group | Experimental | Participants receive repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex at 5 Hz, 120% of the resting motor threshold, for 10 sessions over two weeks. |
|
| Sham Stimulation | Sham Comparator | Participants receive sham stimulation using the same coil positioning and session structure as the active rTMS group, but without active magnetic output. Sham sessions match the schedule and duration of the intervention arm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active Repetitive Transcranial Magnetic Stimulation (rTMS) | Device | Repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex using a figure-8 coil. Stimulation delivered at 5 Hz, 120% of the resting motor threshold, 600 pulses per session, for 10 sessions over two weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive Function Measured by the Montreal Cognitive Assessment (MoCA) | The Montreal Cognitive Assessment (MoCA) is a validated screening tool assessing attention, executive function, memory, language, visuospatial abilities, and orientation. Scores range from 0 to 30, with higher scores indicating better cognitive performance. The outcome is defined as the change in total MoCA score from baseline to post-intervention. | Baseline and after 2 weeks of intervention |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gaziantep University | Gaziantep | Turkey (Türkiye) |
Individual participant data will not be shared because the study involves a small sample size from a single clinical center, and the available data contain identifiable health information that cannot be fully anonymized for public release. No data-sharing infrastructure or repository has been established for this project.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D003072 | Cognition Disorders |
| D020233 | Gait Disorders, Neurologic |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Sham Repetitive Transcranial Magnetic Stimulation | Device | Sham stimulation performed using the same coil placement, session duration, and procedures as the active rTMS condition, but without magnetic output. Sessions matched in schedule and structure to the active intervention. |
|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |