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Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High frequency rTMS | Experimental | Real rTMS, one session per day, for 10 days |
|
| High frequency rTMS with cognitive training | Experimental | Real rTMS and cognitive training, one session per day, for 10 days |
|
| Sham rTMS | Sham Comparator | Sham rTMS, one session per day, for 10 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rTMS | Device | High frequency rTMS for 3 to 10 min to increase the excitability of cortex. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Repeatable Battery for the Assessment of Neuropsychological Status | This battery measures the cognitive functions including attention, memory, language, visuospatial domains. | up to 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Montreal Cognitive Assessment ; MoCA | Assessing cognitive function including delaying recall, attention, executive function, language... | up to 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Po-Yi Tsai, MD | Contact | 886-22875729 | 3 | vivitsai0518@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Po-Yi Tsai, MD | Taipei Veterans General Hospital, Taiwan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taipei Veteran General Hospital | Recruiting | Taipei | 11217 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19309294 | Result | Preston G, Anderson E, Silva C, Goldberg T, Wassermann EM. Effects of 10 Hz rTMS on the neural efficiency of working memory. J Cogn Neurosci. 2010 Mar;22(3):447-56. doi: 10.1162/jocn.2009.21209. |
| Label | URL |
|---|---|
| Description Related Info | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Real rTMS, sham rTMS
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| Cognitive training program | Behavioral | A rehabilitation protocol that facilitates attention, memory, execution. |
|
| Description Related Info | View source |
| Description Related Info | View source |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |