Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High frequency rTMS plus fNIRS | Experimental | rTMS with neuroimage assessment of functional near infrared spectroscopy |
|
| Sham rTMS | Sham Comparator | Sham stimulation |
|
| High frequency rTMS | Experimental | High frequency rTMS to modulate brain areas |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional near infrared spectroscopy | Device | Using high-sensitivity infrared to detect the active brain areas |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Repeatable Battery for the Assessment of Neuropsychological Status | Test cognition including memory, attention, language... | Up to 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Montreal Cognitive Assessment | Test cognition including memory, attention, and language. | Up to 12 weeks |
| Change of Fugl-Meyer Assessment , Wolf Motor Function Test | Test upper limb motor function. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of hand grip, pinch power | Test hand strength. | Up to 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Po-Yi Tsai, MD | Contact | 886-228757293 | vivitsai0518@gmail.com | |
| Chih-Jou Lai, MD | Contact | 886-228757361 | milly1204@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Po-Yi Tsai, MD | Taipei Veterans General Hospital, Taiwan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taipei Veterans General Hospital | Recruiting | Taipei | 11217 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34773596 | Derived | Chang PW, Lu CF, Chang ST, Tsai PY. Functional Near-Infrared Spectroscopy as a Target Navigator for rTMS Modulation in Patients with Hemiplegia: A Randomized Control Study. Neurol Ther. 2022 Mar;11(1):103-121. doi: 10.1007/s40120-021-00300-0. Epub 2021 Nov 13. | |
| 32159313 | Derived | Tsai PY, Lin WS, Tsai KT, Kuo CY, Lin PH. High-frequency versus theta burst transcranial magnetic stimulation for the treatment of poststroke cognitive impairment in humans. J Psychiatry Neurosci. 2020 Jul 1;45(4):262-270. doi: 10.1503/jpn.190060. |
| Label | URL |
|---|---|
| Document of rTMS effect in functional facilitation | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| rTMS | Device | To modulate brain cortex |
|
| Up to 12 weeks |
| 25218256 | Derived | Lai CJ, Wang CP, Tsai PY, Chan RC, Lin SH, Lin FG, Hsieh CY. Corticospinal integrity and motor impairment predict outcomes after excitatory repetitive transcranial magnetic stimulation: a preliminary study. Arch Phys Med Rehabil. 2015 Jan;96(1):69-75. doi: 10.1016/j.apmr.2014.08.014. Epub 2014 Sep 11. |
| Document of rTMS effect in functional facilitation | View source |
| Document of rTMS effect in functional facilitation | View source |