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People with acute inferior wall myocardial infarction will be given an intravenous drug called atropine that increases the heart rate to check if it prevents heart rhythm disturbances during performing coronary intervention
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atropine arm | Active Comparator | This group will receive intravenous atropine 1 mg immediately before wire crossing |
|
| Placebo arm | Placebo Comparator | This group will receive intravenous normal saline immediately before wire crossing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous atropine immediately before wire crossing during primary percutaneous coronary intervention | Drug | Intravenous atropine 1 mg immediately before wire crossing during primary percutaneous coronary intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Conduction abnormalities | Occurrence of conduction abnormalities | Periprocedurally |
| Reperfusion arrhythmias | Occurrence of reperfusion arrhythmias | Periprocedurally |
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiac events | Inhospital major adverse cardiac events including all-cause mortality, cardiovascular mortality, stroke and myocardial infarction | Periprocedurally |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | Abbasia | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42305382 | Derived | Rashed MI, Bastawy IM, Mohamed AL, Elewa MG. Intravenous Atropine in Reducing Reperfusion Arrhythmias, Conduction Abnormalities, and Hypotension in Inferior ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Saudi Heart Assoc. 2026 May 25;38(2):10. doi: 10.37616/2212-5043.1505. eCollection 2026. |
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| Intravenous normal saline as placebo immediately before wire crossing during primary percutaneous coronary intervention | Drug | Intravenous normal saline as placebo immediately before wire crossing during primary percutaneous coronary intervention |
|
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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