Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients

Assessing the Impact of Aminophylline in the Reversal of Complete Heart Block Secondary to Inferior Wall MI in Atropine Resistant Patients: An Open Label Non-randomized Clinical Trial

In this study, the investigator will evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall myocardial infarction (MI)

Administration of Aminophylline can result in reversal of complete heart block in a significant number of atropine resistant patients with inferior wall MI. Hence, in this study our primary aim is to evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall MI.

Inclusion Criteria:

• Adult patients admitted with recent acute inferior wall myocardial infarction (MI)
• Hemodynamically stable blood pressure
• Complete heart block with Narrow QRS < 120 ms and ventricular rate >40/min persisting for at least 6 hours, resistant to atropine
• Temporary pacemaker (TPM) already placed
• Patient asymptomatic with a mean arterial pressure of greater than 65 mmHg with TPM rate placed at 40/min

Exclusion Criteria:

• Patients with cardiogenic shock
• Patients with preexisting permanent pacemaker and Implantable Cardioverter Defibrillator (ICD).
• Patients with a prior history of AV block
• Drugs with dromotropic effects (beta blocker, calcium channel blocker, inotropes)
• Known liver disease (cirrhosis, hepatitis)
• Hypothyroidism
• Unable to consent