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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-013681-92 | Registry Identifier | EUDRACT |
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Aim of the study is to evaluate the benefits from adjunctive intracoronary administration of adenosin in elective patients undergoing coronary angioplasty.
This study will investigate the effects of adjunctive intracoronary administration of adenosine on periprocedural myocardial infarction as compared to placebo.
This is a double-blind randomized trial single-center study. The enrollment will last 10 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Intracoronary Placebo administration |
|
| Adenosine | Active Comparator | Intracoronary adenosine administration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adenosine | Drug | Intracoronary adenosine administration (180 ug for LCA and 120 ug for RCA) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Increase in troponin I (> 3 times the upper normal limit) | At 12 hours after the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| MACE(death, MI, urgent target-vessel revascularization) | 72 hours | |
| Angiographic Coronary flow, as evaluated by corrected TIMI frame count. | 1 minute after the final stent implantation |
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Inclusion Criteria:
Exclusion Criteria:
Marked Bradycardia (< 40 bpm)
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| Name | Affiliation | Role |
|---|---|---|
| Giuseppe De Luca, MD | AOU Maggiore della Carità | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Giuseppe De Luca | Novara | 28100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22000773 | Derived | De Luca G, Iorio S, Venegoni L, Marino P. Evaluation of intracoronary adenosine to prevent periprocedural myonecrosis in elective percutaneous coronary intervention (from the PREVENT-ICARUS Trial). Am J Cardiol. 2012 Jan 15;109(2):202-7. doi: 10.1016/j.amjcard.2011.08.027. Epub 2011 Oct 14. |
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| ID | Term |
|---|---|
| D000241 | Adenosine |
| ID | Term |
|---|---|
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| Placebo |
| Drug |
Intracoronary Placebo administration |
|
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |