This 4-week, mono-centric clinical study employed a randomized three-arm design to evaluate the efficacy of a test serum. The study compared three interventions: the test serum used alone, the test serum used in combination with hyaluronic acid (HA) injection, and HA injection alone. It aimed to assess their effects on skin quality and wrinkles in 90 healthy Chinese female subjects aged 25-40. Evaluations were conducted at multiple timepoints through clinical assessments, instrumental measurements, and image analysis.

Inclusion Criteria:

1. Chinese female with 25-40 years old.

2. All skin types by subjects' self-perceived.

3. Willing to perform HA injection.

4. Did not perform any of the beauty procedure projects in the past 6 months.

5. Lack of hydration, radiance, brightness, smoothness, firmness and elasticity by self-claimed.

6. Presenting with corresponding severity for the attribute evaluated by Dermatologist included:

   • Radiance, smoothness, elasticity, cheek plumpness and firmness: 3≤grade≤6.
   • Global fine lines: 3≤grade.
   • Underneath eye wrinkles: 2≤grade≤5.
   • Forehead wrinkles: 1\