12-Week Study on the Efficacy of Two Serums in Improving Skin Aging and Tone

12-Week Serum Efficacy Study

This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks.

A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.

Inclusion Criteria:

1. Chinese female aged 18-45 years (evenly split among Early aging [18-29 years] and Mature aging [30-45 years]).

2. All skin types (dry, normal, oily, or mixed).

3. Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed.

4. Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

   • Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9);
   • Size of acne marks (PIH): size ≥ 2;
   • Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57).

5. Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

   • Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9);
   • Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57);
   • Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33);
   • Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41).

6. Regular user of serum and sunscreen products.

7. Did not participate in any clinical test or cosmetic product test on skin within the last 3 months.

8. No exclusion by dermatologist due to other medical or dermatological reasons.

9. In general good health at the time of the study.

10. Willing and able to participate as evidenced by signing of informed consent and photo release form.

11. Must be willing to comply with all study protocol requirements (including using only the skincare products provided during the study and not taking topical or oral treatments such as retinol, hormones, or antioxidant health supplements).