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| Name | Class |
|---|---|
| Grenoble Institut des Neurosciences | OTHER |
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Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).
The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.
Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients' short and long-term vital and functional prognosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental | Experimental | Every patient will perform classic brain MRI with additional MRF sequences. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Achieva 3.0T dStream Philips | Device | Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS). |
| Measure | Description | Time Frame |
|---|---|---|
| Success rate and interpretability of images acquired in MRF | Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable) | From enrollment to the end of the MRI exam |
| Measure | Description | Time Frame |
|---|---|---|
| Characterize and extract the physical parameters of the signal acquired with MRF. | Comparison of MRF imaging metrics: signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), using mean values per ROI (region of interest). Segmentation and comparison of lesions, with calculation of the Dice similarity coefficient and/or SSIM (Structural SIMilarity). Visualization and description of artifacts encountered during acquisition (e.g., motion). Quantification of delays: Acquisition time: retrieval of raw data directly from MRI consoles. Reconstruction time: measurement of computation times. Extraction of information on cerebral microvas |
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Inclusion Criteria:
Exclusion Criteria:
* MRI contraindications
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zaza Putkaradze, Dr | Contact | 0476767842 | zputkaradze@chu-grenoble.fr |
| Name | Affiliation | Role |
|---|---|---|
| Loïc LEGRIS, Dr | llegris@chu-grenoble.fr | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Grenoble Alpes | Grenoble | 38043 | France |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| From enrollment to the end of the MRI exam |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |