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Ischemic strokes are the first cause of handicap in adult people, the second cause of dementia and the third cause of death in France. Brain Magnetic Resonance (MR) initial assessment is mandatory to get the right diagnosis, to exclude hemorrhagic lesions and to determine the best treatment.
The conventional diffusion weighted imaging sequence is used to establish the diagnosis and to estimate the volume of ischemic lesions. The perfusion weighted imaging sequences are also used to assess the diffusion-perfusion mismatch which is supposed to be the ischemic penumbra corresponding to territories that could be saved with appropriate treatments.
IntraVoxel Incoherent Motion (IVIM) is a multi-b diffusion sequence which allows to extract four quantitative variables (D, D*, f, ADC) related to the true molecular diffusion and correlated to the microvascular perfusion.
It's a quick sequence with no need of contrast injection and allowing a perfect coregistration with the true diffusion. It has been validated in many pathologies but not in acute strokes.
The feasibility of this sequence in acute ischemic strokes has already been assessed with interesting results.
The study aims to assess the correlation between the quantitative values of IVIM at initial MR exam and the modified Rankin Scale (mRS) score 3 months after an acute ischemic stroke.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IntraVoxel Incoherent Motion sequence | Device | The IVIM diffusion sequence with a duration of 2 minutes is added to the imaging protocol. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between quantitative values of IntraVoxel Incoherent Motion at initial Magnetic Resonance Imaging (MRI) and the modified Rankin Scale (mRS) at 3 months after an acute ischemic stroke. | IntraVoxel Incoherent Motion is a diffusion sequence which allows to extract four quantitative variables (D, D*, f, ADC) related to the true molecular diffusion and correlated to the microvascular perfusion. We aim to assess the correlation between the quantitative values of IVIM at initial exam and the mRS score 3 months after an acute ischemic stroke. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with an acute ischemic stroke
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| Name | Affiliation | Role |
|---|---|---|
| Augustin Lecler, MD | Fondation Ophtalmologique A. de Rothschild | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Ophtalmologique A. de Rothschild | Paris | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41862395 | Result | Sajust de Bergues de Escalup A, Duron L, Seners P, Sabben C, Obadia M, Yavchitz A, Savatovsky J, Lecler A. Prediction of functional outcome in patients with ischemic stroke using advanced diffusion-weighted MRI parameters at 3 Tesla. Diagn Interv Imaging. 2026 Mar 19:S2211-5684(26)00049-5. doi: 10.1016/j.diii.2026.03.001. Online ahead of print. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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