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| Name | Class |
|---|---|
| Centre National de la Recherche Scientifique, France | OTHER |
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The goal of this proof of concept study is to determine if the visualization of the middle cerebral artery and its perforators, through 3D transtemporal ultrasound imaging, is possible thanks to an off-line analysis by 3D ultrasound localization microscopy. Visualization of these vessels would allow us to conclude on the presence, or absence, of an ischemic stroke in the region of the middle cerebral artery.
To answer the question asked, 20 participants who suffered a stroke will carry out a transtemporal ultrasound examination specifically for research in the 7 days following his stroke. The data obtained will be analyzed by the CNRS medical imaging laboratory, in order to characterize the presence of a stroke and to compare the data obtained with that of standard examinations (CT and MRI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort group | Experimental | Routine care + transtemporal ultrasound examination with contract product during hospitalization |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transtemporal ultrasound with contrast product (Sonovue) | Procedure | During their hospitalization and in the 7 days following their stroke, all patients will perform a transtemporal ultrasound including the use of Sonovue contrast product. The examination will last 1 hour and will be carried out on the opposite side of the stroke then on the side of the stroke |
| Measure | Description | Time Frame |
|---|---|---|
| Describe the vascular mapping obtained by 3D transcranial ULM of patients with ischemic stroke in the territory of the middle cerebral artery and its perforators | Measure of the caliber of visible vessels (mm) | Day 1 |
| Describe the vascular mapping obtained by 3D transcranial ULM of patients with ischemic stroke in the territory of the middle cerebral artery and its perforators | Measure of the number of visible vessels (number) | Day 1 |
| Describe the vascular mapping obtained by 3D transcranial ULM of patients with ischemic stroke in the territory of the middle cerebral artery and its perforators | Measure of the speed of the flows (mm/sec) | Day 1 |
| Describe the vascular mapping obtained by 3D transcranial ULM of patients with ischemic stroke in the territory of the middle cerebral artery and its perforators | Measure of the directionality of the flows | Day 1 |
| Describe the vascular mapping obtained by 3D transcranial ULM of patients with ischemic stroke in the territory of the middle cerebral artery and its perforators | Measure of the diffusion index | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Compare 3D ULM with standard stroke imaging methods (TOF MRI and DWI) | vessels caliber (mm) | Day 1 |
| Compare 3D ULM with standard stroke imaging methods (TOF MRI and DWI) | visible vessels (number) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elena MESEGUER, Dr | Contact | 01.40.25.70.33 | +33 | elena.meseguer@aphp.fr |
| Marine CAMUS, Mrs | Contact | 01.40.27.40.76 | +33 | marine.camus2@aphp.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Bichat | Recruiting | Paris | Île-de-France Region | 75018 | France |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C420843 | contrast agent BR1 |
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Proof of concept, exploratory, single group, non-comparative, uncontrolled study
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| Day 1 |
| Compare 3D ULM with standard stroke imaging methods (TOF MRI and DWI) | stroke size (mm3) | Day 1 |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |