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The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants starting with experimental condition | Experimental | Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex |
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| Participants starting with control condition | Active Comparator | Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation | Device | Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
|
| Measure | Description | Time Frame |
|---|---|---|
| Emotional valence for aversive pictures | The mean valence rating of aversive pictures as assessed by a visual analogue scale assessed directly after TMS. | Immediately after the intervention, lasting for approximately 7 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Emotional arousal | The mean arousal rating of aversive pictures as assessed by a visual analogue scale assessed directly after TMS. | Immediately after the intervention, lasting for approximately 7 minutes |
| Aversive episodic memory |
| Measure | Description | Time Frame |
|---|---|---|
| Emotional valence for non-aversive pictures | The mean valence rating of non-aversive pictures as assessed by a visual analogue scale assessed directly after TMS. | Immediately after the intervention, lasting for approximately 7 minutes |
| Emotional arousal for non-aversive pictures |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ehssan Amini, MD | Contact | +41 61 207 02 26 | ehssan.amini@unibas.ch |
| Name | Affiliation | Role |
|---|---|---|
| Dominique de Quervain, MD | University of Basel, Division of Cognitive Neuroscience | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Basel, Division of Cognitive Neuroscience | Recruiting | Basel | Canton of Basel-City | 4055 | Switzerland |
All IPD (de-identified) that underlie results in a publication will be shared upon reasonable request
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All IPD (de-identified) that underlie results in a publication will be shared upon reasonable request for scientific purposes. A reasonable request consists of a short description of the scientific purpose. Requests will be reviewed by the team of the principle investigator.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Oct 20, 2025 |
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| Control continuous 30 Hz thetaburst transcranial magnetic stimulation | Device | Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
|
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Number of aversive pictures remembered in a free recall pictorial task using IAPS picture set
| Approximately one hour after the intervention |
The mean arousal rating of non-aversive pictures as assessed by a visual analogue scale assessed directly after TMS. |
| Immediately after the intervention, lasting for approximately 7 minutes |
| Non-aversive episodic memory | Number of non-aversive pictures remembered in a free recall pictorial task using IAPS picture set | Approximately one hour after the intervention |
| Oct 23, 2025 |
| Prot_SAP_000.pdf |