Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance

A Pilot Study on the Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance

A pilot study, examining the effect of repeated transcranial magnetic brain stimulation (rTMS) on the formation of memories with negative valence. The investigators hypothesize that an effective rTMS protocol to reduce memory performance for adverse events can be found.

Inclusion Criteria:

• Male or female
• Generally healthy
• Normotensive (BP 90/60mmHg - 140/90mmHg)
• BMI: 19 - 30 kg/m2
• Age: 18 - 30 years
• Fluent German-speaking

Exclusion Criteria:

• Metal in the brain, skull or elsewhere in the body (e.g., splinters, fragments, clips, etc.)
• Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
• Cardiac pacemaker or intracardiac lines
• Medication infusion device
• Nonremovable Piercings in the head area, pivot teeth (retainers are no exclusion criterion)
• Tattoos (head area) less than 3 months old or older than 20 years
• Condition after neurosurgery
• Hearing problems or tinnitus
• Not able to sit still due to tremor, tics, itching
• History of repeated syncope
• Head trauma diagnosed as concussion or associated with loss of consciousness
• diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family
• TMS in the past showing problems
• Surgical procedures to spinal cord
• Spinal or ventricular derivations
• Alcohol or drug intake 48 hours before start of visits
• Regular intake of any medication or CNS-active medication 48h before visit
• rMT above the limits of rTMS device.