Active brain stimulation on the right superior frontal cortex using the cTBS 30 Hz protocol

Active brain stimulation on the right superior frontal cortex using the 20 Hz online protocol

Active brain stimulation on the right superior frontal cortex using the 1 Hz offline protocol

Brain stimulation on the dominant temporo-occipital cortex using 10% maximum system output (MSO) and 20 Hz online protocol.

rTMS using cTBS protocol with the following characteristics:

• Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
• Intensity: 0%
• Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
• Duration: 40 seconds for each hemisphere, 80 seconds in total.
• Timing: Immediately before viewing pictures in pictorial memory task (off-line)

rTMS using cTBS protocol with the following characteristics:

• Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
• Intensity: 80% of resting motor threshold (rMT)
• Location: Right superior frontal cortex
• Duration: 40 seconds for each hemisphere, 80 seconds in total.
• Timing: Immediately before viewing pictures in pictorial memory task (off-line)

rTMS using high frequency protocol with the following characteristics:

• Frequency: 20 Hz
• Intensity: 120% of rMT for rMT < 54% & 65% of MSO for rMT ≥ 54%
• Location: temporo-occipital cortex of the dominant brain hemisphere
• Duration: 20 minutes, continuously
• Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.

rTMS using Low frequency protocol with the following characteristics:

• Frequency: 1 Hz
• Intensity: 110% of rMT
• Location: temporo-occipital cortex of dominant brain hemisphere (MNI left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
• Duration: 30 minutes, continuously
• Timing: Starting 10 minutes before and continuing during the picture viewing and valence rating of the pictures of the memory task (on-line).

• Frequency: 20 Hz
• Intensity: 10% of MSO
• Location: temporo-occipital cortex of the dominant brain hemisphere
• Duration: 20 minutes, continuously
• Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.

• Frequency: 20 Hz
• Intensity: 120% of rMT for rMT < 54% & 65% of MSO for rMT ≥ 54%
• Location: right superior frontal cortex of the dominant brain hemisphere
• Duration: 20 minutes, continuously
• Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.

• Frequency: 1 Hz
• Intensity: 110% of rMT
• Location: Right superior frontal cortex of the dominant brain hemisphere
• Duration: 6 minutes
• Timing: Starting 1 minutes before and continuing during the memory task (Online)

• Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
• Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
• Intensity: 100% of resting motor threshold (rMT)
• Location: consecutively on right superior frontal cortex
• Duration: 33.3 seconds for each side
• Timing: Immediately before pictorial memory task (off-line)

• Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
• Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
• Intensity: 100% of resting motor threshold (rMT)
• Location: consecutively on left and right temporo-occipital cortex
• Duration: 33.3 seconds for each side
• Timing: Immediately before pictorial memory task (off-line)