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Background: Placement of implants in an atrophic posterior ridge is a challenge for so many clinicians. The success of dental implants depends on the volume of alveolar bone available to provide stability. Bone grafting using xenograft with PRF and e-PRF as a membrane has shown promising results in both bone healing and defect reconstruction. Aim of the study: to evaluate the effect of Platelet-rich fibrin (PRF) and Extended Platelet-rich fibrin (e-PRF) as a membrane with xenograft to increase the width of ridge in posterior mandible with simultaneous implant placement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF | Active Comparator |
| |
| e-PRF | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| e-PRF membrane will be used with xenograft simultaneously with implant placement. | Other | Peripheral blood is collected in plain tubes and centrifuged (700-2000 g, 8 min) to separate plasma from red cells. The first 2-4 mL of platelet-poor plasma (PPP) is withdrawn and heated at 75 °C for 10 minutes to form albumin gel, then cooled for 1-2 minutes. Meanwhile, the remaining blood fractions (buffy coat, liquid PRF, red cells) are kept cooled to prevent premature clotting. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in implant stability | Osstell device will be used to measure the implant stability, primary stability Just after implant placement, and secondary stability 6 months from the time of implant placement. The measured values will be recorded in ISQ from 1 to 100, Implant stability is directly proportional to ISQ value | baseline and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| change in pain scores | Visual Analogue Scale (VAS) will be used to assess pain for 7 days postoperatively using a 10-point (0-1= None, 2-4= Mild, 5-7= Moderate, 8-10= Severe) | uo to 7 days |
| Change in edema scores |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt | Alexandria | Azarita | 00203 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41896835 | Derived | Abla MMA, Shaaban AM, Younis PA. Comparing two types of platelet-rich fibrin membranes in the management of dehiscence defects with simultaneous implant placement in the posterior mandible: a randomized controlled trial. BMC Oral Health. 2026 Mar 27;26(1):591. doi: 10.1186/s12903-026-08043-w. |
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|
| PRF membrane will be used with xenograft simultaneously with implant placement | Other | Peripheral blood is collected in 9-10 mL additive-free tubes and centrifuged horizontally at 700-2000 g for 8 minutes. |
|
Assessment of edema will be done immediately, post-operative on the 2nd, 3rd, and 7th days as follows:
no inflammation= none intraoral swelling confined to the surgical field = mild extraoral swelling in the surgical zone= moderate extraoral swelling spreading beyond the surgical zone= intense
| up to 7 days |
| change in bone width gain | CBCT will be used | baseline and 6 months |
| change in bone density | CBCt will be used | baseline and 6 months |