The main objective of this clinical trial study is to consider the effect of Platelet-Rich-Factor (PRF) on implant stability and marginal bone resorption around dental implants.

Dental implants were placed in 30 subjects who have 1 or 2 missing teeth in both side of posterior mandible. Implants with a length of 11.5 and a diameter of 4.5 mm will be inserted in both sides. In one side PRF will be instilled after surface treatment with PRF before implant placement, while no PRF was added in other side to serve as control group. All implants will be followed with stability measurement by means of resonance frequency analysis at baseline, and every two weeks up to 3 months. Bone height was measured on medial & distal side on standardized IOPA x-rays.

Inclusion Criteria:

• patients who have 1 or 2 missing teeth in both side of posterior mandible

  • adequate bone quantity and quality at the implant site
  • the implant sites with at least 3 months of healing after extraction,
  • patients well motivated for implant therapy and maintaining good oral hygiene
  • the implant sites with width and length to installation of an implant of 4.5 mm x 11.5 mm.
  • Patients who gave written informed consent

Exclusion Criteria:

• • medically compromised or patients taking any immunosuppressive drugs which may complicate the treatment outcome

  • infection around the implant site
  • history of bruxism/parafunctional habits
  • patients with history of any bleeding disorder or on anti-coagulant therapy.
  • pregnant patients