Influence of Human Platelet Derivatives on Dental Implant

Influence of Human Platelet Derivatives on Dental Implant Osseointegration

The goal of this randomized controlled trial is to evaluate the benefit of PRF membrane on bone around dental implant in patients who need treatment with dental implant.

Aims of the study:

• To study the effect of PRF membrane (with or without bone substitute on increasing bone dimension around dental implant.
• To investigate the effects of compositions of PRF (platelets count, WBC count) on bone healing.

Materials and methods:

PRF will be obtained from a blood sample that is taken from the patient at the time of surgery in 10-mL tubes, the blood-containing tube is placed in a centrifuge at specially controlled rotations, temperature and time. The result is the separation of blood, basically from two by-products, including PRF. The PRF clot will be placed in specific box ( P.R.F -System; Surgident, CE ) to create a PRF membrane with specific thickness that will be placed on the bone around dental implant.

Evaluation of the results

• Alveolar bone width around dental implant will be measured.
• Histological examination of the tissue that excised during dental implant uncover surgery.
• Evaluate pain by visual analogue score (VAS).
• Estimate the count of WBC and platelets in whole blood will be obtained from a laboratory results.

IInclusion criteria

• Non- smoker.
• No medical history of any systemic diseases that affect the bone metabolism.
• Did not receive any systemic drugs.
• Has edentulous area that needs dental implant.

The exclusion criteria were as follows:

• Systemic disease or medication compromising bone and soft tissue healing.
• Pathology in the edentulous region.
• Bruxism.
• Disease of the oral mucosa.