The Effect of Trans-cranial Direct Current Stimulation and Cognitive Rehabilitation on Cognitive Functions and Neuronal Plasticity inPatients With Multiple Sclerosis: A Randomized Controlled Trial
The Effect of Trans-cranial Direct Current Stimulation and Cognitive Rehabilitation on Cognitive Functions and Neuronal Plasticity inPatients With Multiple Sclerosis: A Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether transcranial direct current stimulation (tDCS) and cognitive rehabilitation can improve cognitive functions and neuronal plasticity in patients with multiple sclerosis (MS). The participant population consists of MS patients (both sexes, adults), who commonly experience cognitive impairment in addition to physical and psychological symptoms.
The main questions it aims to answer are:
Does tDCS applied over the left dorsolateral prefrontal cortex improve cognitive abilities in MS patients?
Does the combination of tDCS and cognitive rehabilitation enhance neuroplasticity, as measured by DTI, BDNF levels, and acetylcholinesterase activity?
Inclusion Criteria:
Age between 20 and 50 years.
Diagnosed with relapsing-remitting multiple sclerosis (RRMS).
Mild disability, defined as EDSS < 5.
Patients who attended the neurology clinic and are willing to participate.
Exclusion Criteria:
Presence of psychiatric disorders requiring treatment with neuroleptics.
History of seizures.
Left-handed individuals.
Recent MS relapse requiring steroid treatment.
Pregnant women.
History of brain surgery or presence of intracranial clips.