Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis

Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis / Améliorer Les capacités Cognitives Par tDCS Chez Les Patients Souffrants de sclérose en Plaques

Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.

tDCS will be used in a sham-controlled, double-blind, randomized, cross-over control trial in MS patients suffering from cognitive impairments and/or motor deficits. After informed consent and recruitment, patients will be randomly (computer method) allocated to real or sham tDCS, that will be applied during working memory and attentional tasks. A few days/weeks after completing one arm, the patients will enter the other arm (double-blind cross-over design).

Baseline and follow-up outcomes about cognitive aptitudes, motor tasks and fatigue will be collected.

Inclusion Criteria:

• MS patients with relapsing remitting MS/secondary progression MS (based on the 2010 revised McDonald criteria)
• Cognitive deficits
• Motor deficits

Exclusion Criteria:

• contraindication to tDCS (seizure or epilepsy, metal in the head, …)
• major psychiatric conditions or major depression
• coexisting instable medical condition
• substance or alcohol abuse
• regular intake of drug that strongly modulate brain excitability
• major sequels from MS preventing participation in the study
• pregnancy