Multi-omics Mechanisms of Lifestyle Intervention in Regulating Blood Glucose

Multiscale Causal Disease Warning and Assisted Diagnosis: Multi-omics Mechanisms of Lifestyle Intervention in Regulating Blood Glucose

The mechanisms by which lifestyle interventions regulate blood glucose remain incompletely understood. Traditional research has predominantly focused on single targets or pathways, making it difficult to comprehensively elucidate the complex biological regulatory networks. This study systematically investigates the effects of lifestyle interventions on blood glucose and explores their molecular mechanisms. Through integrated multi-omics analysis-including genomics, proteomics, metabolomics, and microbiomics-investigators aim to identify key biological pathways and molecular targets through which dietary, exercise, and other lifestyle interventions influence glucose regulation, as well as discover biomarkers that reflect the efficacy of these interventions. Building upon these findings, investigators will establish a multi-omics molecular network model linking lifestyle interventions to glucose regulation and develop an auxiliary decision-making system for personalised diabetes diagnosis and treatment.

Inclusion Criteria:

• Aged 18-70 years

Exclusion Criteria:

• Severe chronic diabetic complications or recent acute diabetic complications
• Type 1 diabetes mellitus
• Early-onset diabetes
• Patients currently using insulin therapy
• Recent severe hypoglycemic episodes
• Secondary obesity
• Pregnancy, severe hepatic/renal diseases, thyroid disorders, acute infections, psychiatric disorders, or other conditions that may interfere with study outcomes