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Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs. low-carbohydrate diet) and intensive lifestyle interventions combined with blood glucose monitoring, glucose regulation of overweight/obesity is affected. To improve the blood glucose and related metabolic indexes of patients with impaired (IGR), establish 1-2 clinical intervention programs for impaired glucose regulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group1 | No Intervention | Researchers conduct health education on patients, including dietary guidance, physical activity guidance, psychological behavior counseling, etc. | |
| Group2 | Experimental | In addition to education, the subjects will consume 2 composite protein solid drinks per day, in conjunction with the three-meal diet to increase satiety and intake of sufficient nutrients |
|
| Group3 | Experimental | In addition to education, the subjects will consume 2 nutrition bars daily to replace the staple food of daily lunch and dinner to help reduce carbohydrate intake and intake of sufficient nutrients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low fat diet intensive intervention | Dietary Supplement | education and Compound protein solid beverage |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fasting blood glucose | ten weeks | |
| Blood glucose 2 hours after meal | ten weeks |
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Inclusion Criteria:
Age 18-65 years old â‘¡ Fasting blood glucose is between 5.6-6.9 mmol/L (100-125mg/dL) or oral glucose tolerance test (OGTT) 2h plasma glucose (2h-PG) is 7.8-11.1 mmol/L (140-200 mg/dL)
24 kg/m2 ≤ BMI ≤ 35 kg/m2
Exclusion Criteria:
Patients diagnosed with diabetes or undergoing diabetes treatment;
Receiving drugs or surgery for weight loss at present or in the past 3 months;
Receiving corticosteroid or thyroid hormone treatment;
Secondary obesity caused by endocrine, genetic, metabolic and central nervous system diseases;
Patients with abnormal liver function (alanine aminotransferase or/and aspartate aminotransferase exceeding the upper limit of normal value 3 times); patients with abnormal renal function (serum creatinine exceeding the upper limit of normal value); suffering from kidney disease and other diseases that need to control protein intake;
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| Name | Affiliation | Role |
|---|---|---|
| Pianhong Zhang | Second Affiliated Hospital, School of Medicine, Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cixi People's Hospital | Cixi | Zhejiang | 315300 | China | ||
| Second Affiliated Hospital of Zhejiang University School of Medicine |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Low-Carbon Water Diet Intensive Intervention | Other | education and Nutrition bar |
|
| Hangzhou |
| Zhejiang |
| 310009 |
| China |
| Jinhua municipal central hospital | Jinhua | Zhejiang | 321000 | China |
| Lishui People's Hospital | Lishui | Zhejiang | 323020 | China |
| Ningbo Huamei Hospital, University of Chinese Academy of Sciences | Ningbo | Zhejiang | 315010 | China |
| Shaoxing People's Hospital | Shaoxing | Zhejiang | 312000 | China |
| The first affiliated hospital of Wenzhou medical university | Wenzhou | Zhejiang | 325000 | China |
| Yuyao People's Hospital | Yuyao | Zhejiang | 315400 | China |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |