The aim of the study is to evaluate and compare the long-term color stability of two bioactive materials used in the management of white spot lesions: Surface Pre-Reacted Glass (S-PRG) containing resin-based light-cured varnish and S-PRG containing prophylaxis paste. The study will assess color changes over a 12-month period to determine which material better maintains aesthetic integrity while providing therapeutic benefits for demineralized enamel surfaces.

White spot lesions (WSLs), particularly prevalent in post-orthodontic patients (up to 96%), pose both aesthetic and pathological challenges due to subsurface enamel demineralization that alters optical properties. Although fluoride-based remineralization therapies can arrest lesion progression, they often fail to restore the natural appearance of enamel, leaving residual opacity.

Surface Pre-Reacted Glass (S-PRG) technology offers a bioactive alternative, releasing multiple therapeutic ions (e.g., fluoride, strontium, silicate) to enhance remineralization, neutralize acids, and exhibit antibacterial effects. S-PRG materials are available in resin-based varnishes and prophylaxis pastes; however, their long-term color stability remains underexplored.

Given that aesthetic outcomes significantly impact patient satisfaction, this study aims to compare the 12-month color stability of S-PRG resin-based varnish versus S-PRG prophylaxis paste. Color changes may result from water sorption, dietary staining, polymer degradation, and ion interaction with oral fluids. The comparison is clinically relevant as both materials utilize the same bioactive core but differ in formulation and application methods.

A 12-month observation period allows assessment under real oral conditions, including pH fluctuations and staining challenges. Objective color evaluation using CIE Lab* values and spectrophotometry ensures standardized, clinically relevant data. The study targets anterior teeth due to their aesthetic significance and addresses a critical gap in the literature, supporting evidence-based selection of materials that balance therapeutic efficacy with long-term aesthetic outcomes in WSL management.

Inclusion Criteria:

• Patient consulting in the outpatient clinic.
• Enamel caries in anterior permanent teeth according to ICDAS-1 and ICDAS-2.
• Good oral hygiene.
• Provide informed consent.
• Cooperative and willing to participate in the trial.
• Male or female.
• Adult patients aged 16 to 35 years.

Exclusion Criteria:

• Spontaneous or elicited pain from caries.
• Tooth mobility.
• Signs of pulpal infection.
• Severe medical conditions that would not allow management in the clinic.
• Hereditary developmental defects such as amelogenesis imperfecta or dentinogenesis imperfecta.
• Known allergies or sensitivities to dental materials, including fluoride
• Inability to return for recall visits.
• Poor oral hygiene.
• Refusal to participate in the study.