Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)

Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)

the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration

The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)

Inclusion Criteria:• Patients free from any systemic diseases that may interfer with the normal healing process.

• Maxillary traumatized or cariously exposed non-vital immature anterior teeth.
• Teeth don't need for post and core as a final restoration.
• Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
• Teeth without anatomical variations

Exclusion Criteria:• Immunocompromised patients

• Teeth with previous endodontic treatment.
• Teeth with internal or external resorption
• Radiographic evidence of root fracture.
• Lack of patient and parent cooperation.
• Presence of periodontal pocket depth more than 4 mm.