Propolis for Management of Chemotherapy-Induced Oral Mucositis in Pediatric Patients

Propolis for Management of Chemotherapy-Induced Oral Mucositis in Pediatric Patients: A Randomized Controlled Clinical Trial With Biochemical Analysis

The goal of this clinical trial is to evaluate the efficacy of propolis in the prevention of oral mucositis and reducing pain score in children undergoing chemotherapy, and assessing its impact on body mass index, pediatric quality of life and total antioxidant assay. The main question it aims to answer is:

What is the effect of propolis on oral mucositis scores in children undergoing chemotherapy?

Participants will:

Take propolis 3 times daily for 21 days follow up weekly for 3 weeks

Inclusion Criteria:

• Children of both genders less than 18 years receiving intensive chemotherapy.

• Oncology patients receiving intensified chemotherapy at Oncology unit, Children's Hospital, Ain Shams University, Egypt, who meet the following criteria:

  • Taking intensified chemotherapy
  • A healthy oral mucosa.

Exclusion Criteria:

• Allergy to bee products.
• Severe systemic illness unrelated to cancer (Diabetes, Hypertension, …)
• Inability to take oral medication or unwillingness to participate in the study
• Radiotherapy in the head and neck area.
• Malignant or potentially malignant lesions of the oral cavity.
• Undergoing any other procedures to prevent oral mucositis except standard oral care.
• Patients are unable to commit to the study.