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The purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.
Patients with head and neck malignancy with inclusion criteria randomly divide in 2 groups and take the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo mouth wash | Placebo Comparator | 10 patients swish & swallow 15 ml placebo mouth wash for at least 5 min from the first session of radiotherapy until the last session |
|
| propolis | Active Comparator | 10 patients swish & swallow 15 ml propolis mouth wash for at least 5 min from the first session of radiotherapy until the last session |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| propolis | Drug | 15 ml mouth wash 3 times a day for the whole period of radiotherapy for 5 min swish and then swallow |
|
| Measure | Description | Time Frame |
|---|---|---|
| NCI.CTC Scale | we use NCI-CTC scale for patients in 2 groups to assess effect of propolis mouth wash on prevention and treatment of mucositis in patients under radiotherapy.We measured signs(size and sypmtoms) of mucositis by NCI-CTC scale and also we assessed the onset of the mucositis to describe the prevention efficacy of propolis. | 9 month |
| Measure | Description | Time Frame |
|---|---|---|
| hyposalivation scale | we use a scale for patients in 2 groups to assess effect of propolis maouth wash on subjective xerostomy and signs of candidiasis in patiants under radiotherapy | 9 month |
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Inclusion Criteria: - age >15
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| arghavan tonkaboni, resident | oral medicine dep, dental school, mashhad university of medical science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mashhad University of Medical Science | Mashhad | Razavi Khorasan Province | Iran |
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| ID | Term |
|---|---|
| D052016 | Mucositis |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D009059 | Mouth Diseases |
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| ID | Term |
|---|---|
| D011429 | Propolis |
| ID | Term |
|---|---|
| D012116 | Resins, Plant |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
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| D009057 |
| Stomatognathic Diseases |
| D053147 |
| Plant Exudates |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |