Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers

Phase I Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers

The purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.

Patients with head and neck malignancy with inclusion criteria randomly divide in 2 groups and take the intervention.

Inclusion Criteria: - age >15

• need of radiotherapy
• at least half of the mouth in the field of radiation
• dose 50 -70 Gy
• head & neck malignancy

Exclusion Criteria:

• systemic disease
• FBS > 150 WBC > 3000
• history of radiotherapy
• need of chemotherapy
• systemic disease