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| ID | Type | Description | Link |
|---|---|---|---|
| R21EY036563 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Eye Institute (NEI) | NIH |
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The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Uveitis Group | Eyes with active inflammation due to various systemic diseases | ||
| Posterior Vitreous Detachment Group | Eyes with vitreous floaters and posterior vitreous detachment | ||
| Healthy/Control Group | Healthy eyes with no history of uveitis, posterior vitreous detachment, or previous eye surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Identification & Measurement of Anterior Chamber Cells | Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size & other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of AC Flare | OCT signal of the aqueous humor will be analyzed and correlated with slit lamp grading by the attending physician. The SUN grading system (scale: 0 to 4+) will be used. | Day 1 |
| Measure of Keratic Precipitates |
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Inclusion Criteria:
Exclusion Criteria:
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Study participants will be recruited from clinical practices of the investigators at Casey Eye Institute of Oregon Health & Science University in Portland, Oregon.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Humberto Martinez, COT, MBA | Contact | 503-494-7712 | martinhu@ohsu.edu | |
| Denzil Romfh, OD | Contact | 503-494-4351 | romfhd@ohsu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Yan Li, PhD | Oregon Health and Science University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Casey Eye Institute - Oregon Health & Science University | Recruiting | Portland | Oregon | 97239 | United States |
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Keratic precipitates (KPs) will be identified from OCT images. The size of the KPs will be compared across different uveitis diagnostic categories. There is no formal grading system for KPs. The investigators will use the typical qualitative assessments of morphology, distribution, and density. For morphology, cells will be described as fine, mutton-fat, stellate, or pigmented. Distribution patterns will be described as Arlt's Triangle, diffuse, central, or ring-shaped. Density will be described as few, moderate, or numerous.
| Day 1 |
| Measure of Vitreous Cells | Vitreous cells will be identified from OCT images. Counting of vitreous cells will be done by computer algorithms. Since vitreous cells are not formally graded or quantified in the SUN system, physician grading will be described as rare, few, moderate, numerous, or sheets and compared against the OCT-derived measurements. | Day 1 |
| Measurement of Vitreous Haze | OCT signal of the vitreous clarity will be compared against clinical grading of vitreous haze. The National Eye Institute (NEI) Grading Scale will be used. Grading will be documented on a scale of 0 = no haze to 4+ = severe haze. | Day 1 |
| ID | Term |
|---|---|
| D014606 | Uveitis, Anterior |
| D000080365 | Birdshot Chorioretinopathy |
| D001528 | Behcet Syndrome |
| D006561 | Herpes Simplex |
| D001171 | Arthritis, Juvenile |
| D025241 | Spondylarthritis |
| D012507 | Sarcoidosis |
| D020255 | Vitreous Detachment |
| ID | Term |
|---|---|
| D015864 | Panuveitis |
| D014605 | Uveitis |
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
| D002825 | Chorioretinitis |
| D012173 | Retinitis |
| D012164 | Retinal Diseases |
| D002833 | Choroiditis |
| D015862 | Choroid Diseases |
| D015866 | Uveitis, Posterior |
| D000080363 | White Dot Syndromes |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014657 | Vasculitis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D056660 | Hereditary Autoinflammatory Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D012873 | Skin Diseases, Genetic |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017445 | Skin Diseases, Vascular |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
| D017193 | Skin Diseases, Viral |
| D012874 | Skin Diseases, Infectious |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D013166 | Spondylitis |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
| D006967 | Hypersensitivity |
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