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| Name | Class |
|---|---|
| Wrocław University of Science and Technology | OTHER |
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Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer scale imaging of biological tissue. Applying the image processing allows us to automatically measure the choroidal thickness with good interclass correlation coefficient to the manual measurements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Uveitis group | |||
| Control group | age and sex matched group to the uveitis group |
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| Measure | Description | Time Frame |
|---|---|---|
| Submacular choroidal thickness in different stages of the disease | OCT EDI recordings processed with developed by researchers methodology for image processing | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| ETDRS Visual Acuity | Visual Acuity will be performed with ETDRS charts different for right and left eye | 1 year |
| The SUN working group grading system for anterior chamber cells | At each visit anterior chamber will be examined to assess anterior chamber cells (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The recorded number of cells will be used to determine the grade according to the SUN criteria. |
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Inclusion Criteria:
To the control group - ability to perform OCT examination
To the uveitis group - with one or more of the following clinical features (as indicators for active state of the disease):
Exclusion Criteria:
To the control group - diagnosed uveitis
In case of all groups:
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Uveitis patients and matched control group
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| Name | Affiliation | Role |
|---|---|---|
| Marta Misiuk-Hojło, Professor | Medical University of Wrocław | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology | Wroclaw | 54-622 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25682177 | Background | Indaram M, Agron E, Clemons TE, Sperduto RD, Wong WT, Ferris FL 3rd, Chew EY; Age-Related Eye Disease Study Research Group. Changes in lens opacities on the age-related eye disease study grading scale predict progression to cataract surgery and vision loss: age-related eye disease study report no. 34. Ophthalmology. 2015 May;122(5):888-96. doi: 10.1016/j.ophtha.2014.12.037. Epub 2015 Feb 11. | |
| 23249705 |
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Intention to share anonymised data of each patient visit in the study
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| ID | Term |
|---|---|
| D014605 | Uveitis |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
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| 1 year |
| The SUN working group grading system for anterior chamber flare | At each visit anterior chamber will be examined to assess anterior chamber flare (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The observed changes will be used to determine the grade according to the SUN criteria. | 1 year |
| AREDS 2008 Clinical Lens Opacity Grading Procedure | Using AREDS system for classifying cataracts from photographs: AREDS Report No. 4 the lens opacity will be graded | 1 year |
| NIH grading system for vitreous cells | At each visit vitreous will be examined to assess vitreous cells (1mm x 3mm slit beam in anterior vitreous). The recorded number of cells will be used to determine the grade according to the NIH criteria. | 1 year |
| NIH grading system for vitreous haze | At each visit vitreous will be examined to assess vitreous haze. The recorded of clarity of posterior pole funduscopy will be used to determine the grade according to the NIH criteria. | 1 year |
| Background |
| Li Y, Lowder C, Zhang X, Huang D. Anterior chamber cell grading by optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 Jan 9;54(1):258-65. doi: 10.1167/iovs.12-10477. |
| 29600118 | Background | Passaglia CL, Arvaneh T, Greenberg E, Richards D, Madow B. Automated Method of Grading Vitreous Haze in Patients With Uveitis for Clinical Trials. Transl Vis Sci Technol. 2018 Mar 23;7(2):10. doi: 10.1167/tvst.7.2.10. eCollection 2018 Mar. |
| 20719302 | Background | Davis JL, Madow B, Cornett J, Stratton R, Hess D, Porciatti V, Feuer WJ. Scale for photographic grading of vitreous haze in uveitis. Am J Ophthalmol. 2010 Nov;150(5):637-641.e1. doi: 10.1016/j.ajo.2010.05.036. Epub 2010 Aug 16. |
| 24835759 | Background | Keane PA, Karampelas M, Sim DA, Sadda SR, Tufail A, Sen HN, Nussenblatt RB, Dick AD, Lee RW, Murray PI, Pavesio CE, Denniston AK. Objective measurement of vitreous inflammation using optical coherence tomography. Ophthalmology. 2014 Sep;121(9):1706-14. doi: 10.1016/j.ophtha.2014.03.006. Epub 2014 May 15. |
| 21652026 | Background | Madow B, Galor A, Feuer WJ, Altaweel MM, Davis JL. Validation of a photographic vitreous haze grading technique for clinical trials in uveitis. Am J Ophthalmol. 2011 Aug;152(2):170-176.e1. doi: 10.1016/j.ajo.2011.01.058. Epub 2011 Jun 8. |