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The goal of this study is to find out if brain stimulation can help people stop skin-picking or nail-biting. The study wants to answer two main questions:
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active multifocal Transcranial Direct Current Stimulation (tDCS) | Experimental | participants receive 13-min of active multifocal tDCS targeting the left dorsolateral prefrontal cortex. tDCS will be delivered offline for 13 minutes (1.5mA, 10 seconds ramp in/out). |
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| sham multifocal Transcranial Direct Current Stimulation (tDCS) | Sham Comparator | Sham stimulation will be identical to active but electrical current will only be ramped in/out at the beginning and end of the 13-min period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wireless Multichannel Transcranial Current Stimulator (tDCS) | Device | tDCS will be delivered for 13 minutes (active) or only at the beginning and end of the 13 minute period (sham) using Neuroelectrics Instrument Controller software and a battery-driven Starstim 8-channel transcranial direct current stimulator with 1cm2 ceramic electrodes and SIGNAGEL conductive saline gel. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in subjective urge | Individuals will rate their urge to pick using a scale (1-10) with a higher score meaning greater urge. They will rate their urge three times in a row, at two different time-points. | baseline and post intervention, approximately 90 minutes |
| Change in subjective distress | Individuals will rate their distress using a scale (1-10) with a higher score meaning greater distress. They will rate their distress three times in a row, at two different time-points. | baseline and post intervention, approximately 90 minutes |
| Change in picking or biting behavioral frequency | Picking or biting behaviors will be assessed via two 6-minute blocks of visual observation, before and after tDCS. The frequency of the behaviors observed will be collected in each block. Change in total frequency between blocks will be calculated. | baseline and post intervention (approximately 90 minutes) |
| Change in picking or biting behaviors duration | Picking or biting behaviors will be assessed via two 6-minute blocks of visual observation, before and after tDCS. Duration of the behaviors observed will be collected in each block. Change in total duration between blocks will be calculated. | baseline and post intervention (approximately 90 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hannah Wild, M.S. | Contact | ‪(859) 414-6962‬ | hannah.wild@uky.edu |
| Name | Affiliation | Role |
|---|---|---|
| Gopalkumar Rakesh, MD | University of Kentucky | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Kentucky | Recruiting | Lexington | Kentucky | 40506 | United States |
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| ID | Term |
|---|---|
| D001733 | Bites and Stings |
| ID | Term |
|---|---|
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Cue exposure | Behavioral | Participants will undergo three, twenty-second trials of exposure to individualized cues at the top of the established urge hierarchy, previously determined to precede picking or biting behaviors before and after tDCS. |
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| Boredom induction | Behavioral | Participants will be left in the testing room without access to a cellphone or reading materials for 2 different 6 minute periods. |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |