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| ID | Type | Description | Link |
|---|---|---|---|
| 2012 YIA | Other Grant/Funding Number | Brain & Behavior Research Foundation |
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In this study the investigators aim to assess whether transcranial direct current stimulation (tDCS; a safe and non-invasive method for modulating the activity of specific brain regions) when applied over the orbitofrontal cortex (OFC) is able to modulate decision-making and impulse control in healthy participants.
In this single-blind, three-arm and sham-controlled study, we will assess whether transcranial direct current stimulation (tDCS; a safe and non-invasive method for modulating the activity of specific brain regions) when applied over the orbitofrontal cortex (OFC) is able to modulate decision-making and impulse control in healthy volunteers. We hypothesize that tDCS applied to the OFC, in comparison to sham tDCS, will significantly enhance decision-making and impulse control. For this study we will enroll 45 healthy individuals aged 18-60 years. These individuals will be assessed with a battery of computerized tasks as well as clinician-administered and self-reported questionnaires on depression and anxiety. Assessments will be carried out before and after a single 30-minute tDCS session.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Left OFC Group | Experimental | Anode applied to the left OFC and cathode applied to the right OFC |
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| Right OFC Group | Experimental | Anode applied to the right OFC and cathode applied to the left OFC |
|
| Sham tDCS | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | Anode placed over the OFC or the DLPFC and cathode placed over the occipital region |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in the net score of the Iowa Gambling Task | Before and after a 30-minute tDCS session |
| Measure | Description | Time Frame |
|---|---|---|
| Change in the "average-adjusted number of pumps" in the Balloon Analog Risk Task | Before and after a 30-minute tDCS session | |
| Change in the number of risky choices in the Game of Dice Task | Before and after a 30-minute tDCS session |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marcelo Berlim, MD, MSc | Neuromodulation Research Clinic, Douglas Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neuromodulation Research Clinic, Douglas Mental Health University Institute | Montreal | Quebec | H4H1R3 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18680573 | Background | Beeli G, Casutt G, Baumgartner T, Jancke L. Modulating presence and impulsiveness by external stimulation of the brain. Behav Brain Funct. 2008 Aug 4;4:33. doi: 10.1186/1744-9081-4-33. | |
| 20105234 | Background | Boggio PS, Campanha C, Valasek CA, Fecteau S, Pascual-Leone A, Fregni F. Modulation of decision-making in a gambling task in older adults with transcranial direct current stimulation. Eur J Neurosci. 2010 Feb;31(3):593-7. doi: 10.1111/j.1460-9568.2010.07080.x. Epub 2010 Jan 25. |
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| ID | Term |
|---|---|
| D007175 | Impulsive Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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|
| Change in the number of commission errors in the Continuous Performance Task | Before and after a 30-minute tDCS session |
| Change in the interference index in the Stroop Color-Word Test | Before and after a 30-minute tDCS session |
| Change in the stop-signal reaction time in the Stop-Signal Task | Before and after a 30-minute tDCS session |
| 17553993 | Background | Fecteau S, Pascual-Leone A, Zald DH, Liguori P, Theoret H, Boggio PS, Fregni F. Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making. J Neurosci. 2007 Jun 6;27(23):6212-8. doi: 10.1523/JNEUROSCI.0314-07.2007. |
| 20335459 | Background | Hecht D, Walsh V, Lavidor M. Transcranial direct current stimulation facilitates decision making in a probabilistic guessing task. J Neurosci. 2010 Mar 24;30(12):4241-5. doi: 10.1523/JNEUROSCI.2924-09.2010. |
| 22347844 | Background | Sela T, Kilim A, Lavidor M. Transcranial alternating current stimulation increases risk-taking behavior in the balloon analog risk task. Front Neurosci. 2012 Feb 14;6:22. doi: 10.3389/fnins.2012.00022. eCollection 2012. |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |