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| Name | Class |
|---|---|
| Ardabil University of Medical Sciences | OTHER |
| Leibniz Research Centre for Working Environment and Human Factors | OTHER |
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This is a randomized, double-blind, parallel-group, sham-controlled trial that aims to investigate the effectiveness of transcranial direct current stimulation (TDCS) on improving symptoms, quality of life, depression, and cognitive functions in 39 patients with obsessive-compulsive disorder (OCD) that are randomized in 3 experimental groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS group 1 | Experimental | In the first experimental group, the TDCS intervention protocol consists of 10 sessions of 20 minutes of 1 mA electrical stimulation on 5 consecutive days with two sessions per day. |
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| tDCS group 2 | Experimental | In the second experimental group, the TDCS intervention protocol consists of 10 sessions of 20 minutes of 2 mA electrical stimulation on 5 consecutive days with two sessions per day. |
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| Control group | Placebo Comparator | In the placebo group, the TDCS intervention protocol consists of 10 sessions of 20 minutes of sham electrical stimulation on 5 consecutive days with two sessions per day. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation | Device | Patients will receive 10 sessions of 20 minutes of either 1 mA, 2 mA or sham electrical stimulation on 5 consecutive days |
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| Measure | Description | Time Frame |
|---|---|---|
| Yale-Brown Obsessive-Compulsive (Y-BOCS) rating scale | Score in the Yale-Brown Obsessive-Compulsive (Y-BOCS). Total scores on the measure range from 0 to 40, with a score of 0-7 indicating subclinical symptoms, 8-15 mild symptoms, 16-23 moderate symptoms, 24-31 severe symptoms and 32-40 extreme symptoms. | up to 1 month after the intervention |
| Beck Anxiety Questionnaire (BAI) | Score in the Beck Anxiety Questionnaire (BAI). The BAI scores are classified as minimal anxiety (0 to 7), mild anxiety (8 to 15), moderate anxiety (16 to 25), and severe anxiety (30 to 63). | up to 1 month after the intervention |
| Response inhibition task 1 | Performance in the response inhibition tasks (Flanker test) | up to 1 month after the intervention |
| Working memory task | Performance in the working memory task as an executive function task | up to 1 month after the intervention |
| Response inhibition task 2 | Performance in the response inhibition tasks (Go/No-Go task) | up to 1 month after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Beck Depression Questionnaire (BDI-II) | Score in the Beck Depression Questionnaire (BDI-II). The BDI-II scores are classified as below: Score of 1-10: These ups and downs are considered normal. Score of 11-16: Mild mood disturbance. Score of 17-20: Borderline clinical depression. Score of 21-30: Moderate depression. Score of 31-40: Severe depression. Score of 40+ Extreme depression. | up to 1 month after the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ardabil University of Medical Sciences | Ardabil | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38316750 | Result | Alizadehgoradel J, Molaei B, Barzegar Jalali K, Pouresmali A, Sharifi K, Hallajian AH, Nejati V, Glinski B, Vicario CM, Nitsche MA, Salehinejad MA. Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial. Transl Psychiatry. 2024 Feb 5;14(1):78. doi: 10.1038/s41398-024-02736-y. |
| Label | URL |
|---|---|
| Published results | View source |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Quality of Life Questionnaire (WHOQUL) | Score in the Quality of Life Questionnaire. It has 26 items and each item is rated on a 5-point scale with a higher score indicative of higher quality of life. | up to 1 month after the intervention |
| electroencephalogram (EEG) oscillatory power | Change in the EEG power in alpha, delta, theta and beta bands | up to 1 month after the intervention |
| electroencephalogram (EEG) functional connectivity | Change in the EEG functional connectivity | up to 1 month after the intervention |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |