tDCS for Treatment Resistant Obsessive Compulsive Disorder

Transcranial Direct Current Stimulation (tDCS) to Treat Patients With Severe and Resistant Obsessive Compulsive Disorder

It's a multicentric, randomized, controlled study concerning 100 patients with treatment-resistant obsessive compulsive disorders (OCD). The aim of this study is to evaluate the effect of transcranial direct current stimulation (tDCS) on OCD patients.

Inclusion Criteria:

• Meets criteria for obsessive compulsive disorder according to Diagnostic and Statistical Manual (DSM IV) with a "good insight" (BABS)

• No current depressive and suicidal risks

• No epileptic pathology

• Age: Participants will be both males and females, 18-70 years of age included.

• Chronic Obsessive compulsive disorder ( Total Y-BOCS>20 or Y-BOCS one subscale > 15)

• Obsessive compulsive disorder resistant to pharmacology treatment :

  1. at least 2 antidepressants (IRS type) (> 12 weeks)
  2. cognitive and comportment therapy since at least one year

• Treatment stability (antidepressants) for more than 12 weeks without significant improvement.

• Affiliation to a social security system (recipient or assignee),

• Signed written inform consent form

Exclusion Criteria:

• Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,
• Patient under curators
• Patient hospitalized under duress
• Meets another diagnosis of axe 1 of DSM-IV
• Current depressive or suicidal risks
• Patient with any form of metal in the cranium, a pacemaker, skull defects, or skin lesions to the scalp (cuts, abrasions, rash)
• Epileptic patient
• Patient with a medical history of cranial trauma
• Patient unable to give his or hers informed consent