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This retrospective, single-center study aims to evaluate the impact of preoperative albumin levels on postoperative outcomes in geriatric patients (aged 65 and above) undergoing cancer surgery. The study will compare postoperative complication rates, length of hospital stay, and intensive care needs between patients with hypoalbuminemia and those with normal albumin levels.
Malnutrition is a significant risk factor for postoperative complications in elderly cancer patients. Preoperative serum albumin is a key biomarker reflecting nutritional and inflammatory status. This study will retrospectively review the medical records of 330 geriatric patients (≥65 years) who underwent cancer surgery at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. Patients will be grouped according to preoperative albumin levels: Group 1 (<3.5 g/dL, hypoalbuminemia) and Group 2 (≥3.5 g/dL, normal). The primary aim is to compare postoperative complication rates, length of hospital stay, and intensive care requirements between these groups. The findings are expected to clarify the prognostic value of albumin and support individualized perioperative management in geriatric cancer surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (<3.5 g/dL, hypoalbuminemia) | Participants with preoperative serum albumin levels less than 3.5 g/dL. This group represents geriatric cancer surgery patients who are considered to have hypoalbuminemia, indicating poor nutritional and/or inflammatory status prior to surgery. | ||
| Group 2 (≥3.5 g/dL, normal) | Participants with preoperative serum albumin levels equal to or greater than 3.5 g/dL. This group represents geriatric cancer surgery patients with normal preoperative albumin levels, reflecting adequate nutritional and inflammatory status prior to surgery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Complication Rate | The proportion of patients experiencing any postoperative complication (including but not limited to pulmonary complications, infections, or other adverse events) within 30 days after surgery, as assessed by clinical records and standardized criteria (e.g., Clavien-Dindo classification) | within 30 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Length of Hospital Stay | Total number of days from the date of surgery to hospital discharge. | postoperative first 30 days |
| Postoperative Intensive Care Unit (ICU) Admission | The proportion of patients requiring ICU admission after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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This study will include geriatric patients aged 65 years and older who underwent elective cancer surgery at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. All participants must have a documented preoperative serum albumin level. Patients with emergency or palliative surgery, active infection or inflammatory disease, or missing/incomplete medical records will be excluded. The study population represents a real-world cohort of elderly cancer patients at increased risk for postoperative complications due to age-related physiological changes and comorbidities.
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| Name | Affiliation | Role |
|---|---|---|
| Mustafa Kemal SAHIN | MUSTAFA KEMAL SAHÄ°N | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation | Ankara | Yenimahalle | 06200 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36455266 | Background | Song S, Qiu P, Wang H, Zhang D, Qi Q, Feng L. Low preoperative serum prealbumin levels and risk of postoperative complications after transsphenoidal surgery in nonfunctioning pituitary adenoma. Neurosurg Focus. 2022 Dec;53(6):E6. doi: 10.3171/2022.9.FOCUS22211. | |
| 27765612 | Background | Caras RJ, Lustik MB, Kern SQ, McMann LP, Sterbis JR. Preoperative Albumin Is Predictive of Early Postoperative Morbidity and Mortality in Common Urologic Oncologic Surgeries. Clin Genitourin Cancer. 2017 Apr;15(2):e255-e262. doi: 10.1016/j.clgc.2016.09.008. Epub 2016 Sep 23. |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D034141 | Hypoalbuminemia |
| D011183 | Postoperative Complications |
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D007019 | Hypoproteinemia |
| D001796 | Blood Protein Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| immediately after the surgery |
| Length of ICU Stay | The total duration of ICU stay following surgery | 30 days after surgery |
| 30-day Postoperative Mortality | All-cause mortality within 30 days after surgery | within 30 days after surgery |
| Incidence of Specific Postoperative Pulmonary Complications | The number of patients developing pulmonary complications (e.g., pneumonia, pleural effusion, atelectasis, ARDS, respiratory failure) within 30 days after surgery | 30 days after surgery |
| 30908744 | Background | Loftus TJ, Brown MP, Slish JH, Rosenthal MD. Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification. Nutr Clin Pract. 2019 Jun;34(3):340-348. doi: 10.1002/ncp.10271. Epub 2019 Mar 25. |
| 33568020 | Background | Heise D, Bednarsch J, Kroh A, Schipper S, Eickhoff R, Lang S, Neumann U, Ulmer F. Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery. Surg Innov. 2021 Dec;28(6):714-722. doi: 10.1177/1553350621991223. Epub 2021 Feb 10. |
| 41840567 | Derived | Sahin MK. Silent threat: how preoperative albumin levels affect geriatric cancer surgery outcomes? BMC Surg. 2026 Mar 16;26(1):292. doi: 10.1186/s12893-026-03659-9. |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |