This is an observational and retrospective cohort study to evaluate the impact of the preoperative serum albumin concentration on postoperative outcomes among hepatocellular carcinoma (HCC) patients who received hepatectomy or liver transplantation.

The impact of hypoalbuminemia on postoperative outcomes has been the subject of several investigations which agreed that hypoalbuminemia is an important risk factor for mortality and morbidity after various types of surgical operations. Unfortunately, there are limited real-world data to establish the correlation between hypoalbuminemia and hepatectomy or liver transplantation postoperative complications in China. This study will evaluate the impact of the preoperative serum albumin concentration on postoperative outcomes among hepatocellular carcinoma (HCC) patients who received hepatectomy or liver transplantation.

Inclusion Criteria:

• Patients who diagnosed with HCC confirmed by histology/cytology or clinically criteria regardless of gender.
• HCC Patients who had received the first hepatectomy or liver transplantation (LT).
• Age ≥18 years at the start date of the hepatectomy or LT.
• HCC patients who had the value of serum albumin within 7 days prior to the surgery.
• HCC patients who had exemption of informed consent.

Exclusion Criteria:

• HCC Patients with extrahepatic metastasis or other malignant tumours.

All patients who met the criteria for inclusion in this real-world study from Zhongshan Hospital, Fudan University will be included. According to a preliminary feasibility department investigation, a sample size of approximately 480 subjects will be enrolled in this study.