Albumin for Hepatocellular Carcinoma | NCT03974074 | Trialant

Albumin for Hepatocellular Carcinoma | NCT03974074 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Albumin infusion group	Experimental	Albumin infusion (20 g, ivgtt, qd) will be performed to patients with HCC after hepatic resection in 24 h for three days. All patients wil receive furosemide (10 mg, iv) after albumin transfusion. In the fifth day after resection, patients will receive albumin transfusion if they have ascites with shifting dullness, moderate edema (below both lower ankle joints) with serum albumin lower than 30 g/L, severe postoperation complication (septicopyemia, postoperative bleeding with reoperation, or biliary fistula).	Drug: Albumin infusion
Empty control	No Intervention	Conventional liver protection and rehydration therapy.In the fifth day after resection, patients will receive albumin transfusion if they have ascites with shifting dullness, moderate edema (below both lower ankle joints) with serum albumin lower than 30 g/L, severe postoperation complication (septicopyemia, postoperative bleeding with reoperation, or biliary fistula).

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Albumin infusion	Drug	Albumin infusion (20 g, ivgtt, qd) will be performed to patients with HCC after resection in 24 h for three days.	Albumin infusion group

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Serum total bilirubin level	Recovery of liver function between the two groups	Change from Baseline total bilirubin at the fifth and seventh days after resection
Serum albumin level	Recovery of liver function between the two groups	Change from Baseline serum albumin at the fifth and seventh days after resection

Secondary Outcomes

Measure	Description	Time Frame
Abdominal girth	Drainage liquid and abdominal girth between the two groups were compared	Change from Baseline abdominal girth at the fifth and seventh days after resection
Rate of postoperative complications

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
20633946	Result	European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 2010 Sep;53(3):397-417. doi: 10.1016/j.jhep.2010.05.004. Epub 2010 Jun 1. No abstract available.
26671516	Result

Condition Browse Module