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Current recommendations do not recommend the concomitant administration of albumin after ascites puncture in patients with ascites neoplasia unlike cirrhotic ascites. The etiology of ascites in cancer patients is multifactorial, particularly by hepatic invasion that can lead to ascites loaded with albumin. Ascites punctures therefore lead to undernutrition, recurrent early ascites by decreasing the oncotic pressure by hypo albuminemia and a state of anasarca affecting the quality of life.
According to the recommendations, each ascites fluid must be sent for biochemical and bacteriological analysis.
Demonstrate the high gradient proportion (percent only, no threshold of significance required). The literature has already validated the importance of supplementing albumen with cirrhotic ascites. Demonstrating that some cancer patients have high gradients, this will be enough to make the practitioner think to supplement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| solid cancer in a palliative situation with ascites | Patient over the age of 18, followed for a solid cancer in a palliative metastatic situation, having had a puncture of ascites. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cirrhotic albumin | Diagnostic Test | Ascites puncture |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Serum-Ascites Albumin Gradient Prevalence | Elevated Serum-Ascites Albumin Gradient Prevalence in Palliative Cancer Patients | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Metastatic sites | Number of Metastatic sites of patients with a high gradient. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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All HDJ, UAI, and the 3 medical oncology departments patients who have ascites puncture may be included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aurélien PROUX | Contact | 0491227643 | PROUXA@ipc.unicancer.fr |
| Name | Affiliation | Role |
|---|---|---|
| Aurélien PROUX | Institut Paoli-Calmettes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Paoli Calmettes | Recruiting | Marseille | Bouches Du Rhone | 13009 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24406314 | Background | Carrier P, Jacques J, Debette-Gratien M, Legros R, Sarabi M, Vidal E, Sautereau D, Bezanahary H, Ly KH, Loustaud-Ratti V. [Non-cirrhotic ascites: pathophysiology, diagnosis and etiology]. Rev Med Interne. 2014 Jun;35(6):365-71. doi: 10.1016/j.revmed.2013.12.001. Epub 2014 Jan 6. French. | |
| Background | Guide pratique des soins palliatifs Edition A.P.E.S. (2008) | ||
| 17298959 |
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| ID | Term |
|---|---|
| D001201 | Ascites |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| serum albumin |
| Diagnostic Test |
blood punctures |
|
| Background |
| Ayantunde AA, Parsons SL. Pattern and prognostic factors in patients with malignant ascites: a retrospective study. Ann Oncol. 2007 May;18(5):945-9. doi: 10.1093/annonc/mdl499. Epub 2007 Feb 13. |