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This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.
The objective of this prospective clinical trial is to compare two mucogingival surgical techniques-coronally advanced flap (CAF) and tunnel technique-used in combination with platelet-rich fibrin (PRF) for treating multiple Miller Class I-II gingival recessions. Eleven systemically healthy participants with bilateral gingival recessions will be enrolled. CAF+PRF will be applied on one side, and Tunnel+PRF on the contralateral side. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level, recession height and width, and keratinized tissue height will be recorded at baseline, 3 months, and 6 months. Root coverage outcomes and clinical attachment gain will be analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAF + PRF | Experimental | This group will receive coronally advanced flap (CAF) surgery combined with platelet-rich fibrin (PRF) for the treatment of multiple gingival recessions. |
|
| Tunnel + PRF | Experimental | This group will receive tunnel surgical technique combined with platelet-rich fibrin (PRF) for the treatment of multiple gingival recessions. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CAF with PRF | Procedure | Coronally advanced flap technique will be performed to reposition the gingival margin coronally. Platelet-rich fibrin (PRF) membranes will be placed over the exposed root surfaces and stabilized with sutures. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Recession Height (RH) | Recession height will be measured in millimeters from the cementoenamel junction to the gingival margin using a periodontal probe at baseline and 6 months postoperatively. | Baseline and 6 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Clinical Attachment Level (CAL) | Clinical attachment level will be measured in millimeters using a periodontal probe to assess periodontal healing at different time points. | Baseline, 3 Months, and 6 Months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Necati Zavrak, RA | Contact | +905367401003 | necatizvrk@gmail.com | |
| Gizem Torumtay Cin, Assoc. Prof. Dr. | Contact | +905053913915 | gyaprak_dt@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gizem TORUMTAY CİN, Assoc. Prof. Dr. | Pamukkale University Faculty of Dentistry, Department of Periodontology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pamukkale University, Faculty of Dentistry, Periodontology | Denizli | 20160 | Turkey (Türkiye) |
This study does not plan to share individual participant data (IPD).
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D056690 | Prolactin-Releasing Hormone |
| ID | Term |
|---|---|
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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Split-mouth randomized design. Each participant receives both interventions, one per side of the mouth.
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The clinical examiner who recorded the outcome measures was blinded to the type of surgical technique applied on each side.
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| Tunnel with PRF | Procedure | A tunnel or subgingival pouch will be created using microsurgical instruments without vertical incisions. Platelet-rich fibrin (PRF) membranes will be inserted into the tunnel and the gingival tissue will be advanced coronally and sutured to cover the recession. |
|
| D055093 |
| Periodontal Atrophy |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |