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The aim of this study was to evaluate the clinical outcomes of platelet- rich fibrin and coronally advanced flap technique in the treatment of multiple gingival recessions in comparison with connective tissue graft technique.
Aim of this study was to evaluate the clinical outcomes of platelet rich fibrin (PRF)+coronally advanced flap (CAF) technique in the treatment of multiple gingival recessions in comparison with connective tissue graft (CTG)+CAF technique.12 patients with bilateral Miller Class I multiple gingival recessions were treated with PRF+CAF (test group) and CTG+CAF (control group) technique in a split-mouth study design. Probing depth, recession depth (RD), clinical attachment level (CAL), recession width, position of gingival margin, papilla width, keratinized tissue height (KTH), keratinized tissue thickness (KTT) were measured at baseline and 3, 6 and 12 months after surgery. Root coverage (RC) and complete root coverage (CRC) ratios were evaluated post-operatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Platelet rich fibrin and coronally advanced flap | Experimental | Coronally advanced flap and platelet rich fibrin were used in treatment arms. |
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| Connective tissue graft and coronally advanced flap | Active Comparator | Coronally advanced flap and connective tissue graft were used in treatment arms. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet rich fibrin and coronally advanced flap | Procedure | CAF were used in treatment arms. Root planning was performed on the exposed part of roots to provide more biocompatible surface for re-attachment. Two 10 cc tubes with clot activator were used to collect blood from the patient; blood was centrifuged at 2700 rpm for 12 min. PRF box was used to form fibrin clots into membranes. PRF was positioned at the level of the cemento-enamel junction (CEJ), and sutured on the periosteum bed with 6/0 absorbable sutures. Gingival margins on the flap were placed at least 1 mm coronally of the CEJ and sutured with 5/0 absorbable sutures. Sutures were removed at 2nd week. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Root Coverage | The percentage of root coverage was calculated according to the preoperative recession depth to postoperative recession depth. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Complete Root Coverage | Complete root coverage was calculated according to measurement of the pre and post operative gingival margin which was above the enamel-sement junction. | 12 months |
| Change from Baseline Keratinized Tissue Width at 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hatice Selin Yıldırım, Dr. | Marmara University, Faculty of Denistry, Department of Periodontology | Study Chair |
| BaÅŸak DoÄŸan, Prof. Dr. | Marmara University, Faculty of Denistry, Department of Periodontology | Study Director |
| Atacan Yavuz, Dr. | Marmara University, Faculty of Denistry, Department of Periodontology | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38691209 | Derived | Yavuz A, Gungormek HS, Kuru L, Dogan B. Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial. Clin Oral Investig. 2024 May 1;28(5):291. doi: 10.1007/s00784-024-05694-3. |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| Connective tissue graft and coronally advanced flap | Procedure | Control sites were treated by coronally advanced flap (CAF) combined with connective tissue graft (CTG). CAF were used in both treatment arms. Root planning was performed on the exposed part of roots to provide more biocompatible surface for re-attachment. CTG was obtained with single incision method. CTG was positioned at the level of the cemento-enamel junction (CEJ), and sutured on the periosteum bed with 6/0 absorbable sutures. Gingival margins on the flap were placed at least 1 mm coronally of the CEJ and sutured with 5/0 absorbable sutures. Sutures were removed at 2nd week. |
|
Width of keratinized tissue at mid-buccal point measured from free gingival margin to mucogingival junction
| 3 months |
| Change from Baseline Keratinized Tissue Width at 6 months | Width of keratinized tissue at mid-buccal point measured from free gingival margin to mucogingival junction | 6 months |
| Change from Baseline Keratinized Tissue Width at 12 months | Width of keratinized tissue at mid-buccal point measured from free gingival margin to mucogingival junction | 12 months |
| Change from Baseline Gingival Thickness at 3 months | Gingival thickness at mid-buccal aspect measured at the center of keratinized tissue. | 3 months |
| Change from Baseline Gingival Thickness at 6 months | Gingival thickness at mid-buccal aspect measured at the center of keratinized tissue. | 6 months |
| Change from Baseline Gingival Thickness at 12 months | Gingival thickness at mid-buccal aspect measured at the center of keratinized tissue. | 12 months |
| D055093 |
| Periodontal Atrophy |