Growth Factors in the Treatment of the Multiple Gingival Recessions

Clinical Evaluation of Treatment With Micro-surgical Management of Type I Multiple Gingival Recessions Using Coronally Advanced Flap With Either Advanced Platelet-Rich Fibrin or Concentrated Growth Factor: A Comparative Analysis

The purpose of this study was to compare and evaluate the clinical effects of Concentrated Growth Factor (CGF) and Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique using a microsurgical approach in the treatment of Type I multiple gingival recessions (GR).

Inclusion Criteria:

• Systematically and periodontally healthy non-smokers
• Presence of Cairo Recession type I gingival recession with ≥ 2 mm gingival recession depth, probing depth <3 mm and gingival thickness (GT) ≥ 0.8 mm on both sides of the maxillary arch
• Width of keratinized gingiva ≥ 2mm
• Presence of identifiable cemento-enamel junction
• Full-mouth plaque index (PI) < 20 %
• Gingival index (GI) scores =1
• Presence of tooth vitality
• Absence of caries, restorations and furcation involvement in the treated area

Exclusion Criteria:

• Patients who had systemic problems that wound contraindicate for periodontal surgery
• Usage of medications known to interfere with healing and to cause gingival enlargement
• Recession defects associated with demineralization, deep abrasion, previous surgery in the defects area within the past 1 year
• Pregnant or lactating females
• Drug and alcohol abuse