The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Analysis of the Relationship Between the Concentration of the Brain Derived Neurotrophic Factor (BDNF) in Plasma, the Occurrence of BDNF Gene Polymorphism (Val66Met) and White Blood Cell Markers and the Incidence of Postoperative Central Nervous System Disorders in Patients Undergoing General Anesthesia for Cardiac Surgery With Extracorporeal Circulation

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Inclusion criteria include:

1. Age > 18 years.
2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
3. Ability to understand and sign an informed consent form.

Exclusion criteria include:

1. Emergency surgery.
2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score <15.
3. Baseline delirium (positive CAM test prior to surgery).
4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
5. Inability to understand Polish language.
6. Inability to give and sign informed consent due to auditory or visual dysfunction.