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In this single center prospective cohort study a total of 100 patients scheduled for elective off-pump CABG will be recruited. They will be allocated to one study and one control group according to the presence or absence of postoperative type 2 neurological complications. The two groups will be compared in terms of serum concentrations of glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) at the time of skin incision and closure as well as 24 hours and 7 days following surgery. Diagnostic performance of these markers for predicting type 2 neurological complications of off-pump CABG will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| type 2 neurological complications present | The group of patients diagnosed with postoperative cognitive dysfunction (POCD) or postoperative delirium (POD), or both concurrently. |
| |
| type 2 neurological complications absent | The group of patients without neurological complications. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exposure to type 2 neurological complications | Other | exposure to postoperative cognitive dysfunction (POCD) or postoperative delirium (POD), or both concurrently. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of serum GFAP concentration (ng/ml) changes. | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of glial fibrillary acidic protein (GFAP). | GFAP concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). |
| Assessment of serum NSP concentration (ng/ml) changes. | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of neuroserpin (NSP). | NSP concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). |
| Assessment of serum pNfH concentration (ng/ml) changes. | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of neuroserpin phosphorylated axonal neurofilament subunit H (pNfH). | pNfH concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). |
| Assessment of serum VILIP-1 concentration (ng/ml) changes. | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of visinin-like protein 1 (VILIP-1). | VILIP-1 concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). |
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Inclusion Criteria:
Exclusion Criteria:
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All participants will be recruited from patients scheduled for elective off-pump CABG at the Department of Cardiac Surgery, Dr Antoni Jurasz Memorial University Hospital, Bydgoszcz, Poland.
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| Name | Affiliation | Role |
|---|---|---|
| Krzysztof Szwed, Dr | Department of Clinical Neuropsychology, Nicolaus Copernicus University, Collegium Medicum. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiac Surgery, Dr Antoni Jurasz Memorial University Hospital | Bydgoszcz | Kuyavian-Pomeranian Voivodeship | 85-094 | Poland |
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Available without time limits.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Serum