Biochemical Predictors of Delirium in Cardiac Surgery

Biochemical Predictors of Delirium in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass

Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.

Inclusion Criteria:

• surgery under cardiopulmonary bypass
• Age > 60 years
• CABG surgery or valve surgery (repair/replacement)

Exclusion Criteria:

• urgent surgery
• surgery on aorta
• combined procedures (CABG+valves)
• significant stenosis of carotid arteries
• Parkinson's disease
• liver cirrhosis
• use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs