The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.

Inclusion Criteria:

• patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma

Exclusion Criteria:

• patient with severe physical diseases that prevented them from adhering to the examination requirements,
• patient with coagulopathy or other contraindications for biopsy or polypectomy,
• patient with previous surgical procedures on the gastrointestinal tract,
• presence of colorectal cancer or other malignant tumor at baseline
• presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
• within 1 month before enrollment, oral antibiotics and probiotics were taken;
• inability to provide informed consent or refusal to participate in the study.

patients with high-risk colorectal polyps