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| ID | Type | Description | Link |
|---|---|---|---|
| APK.002.122.2022 | Other Identifier | University of Bialystok |
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Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.
Forty subjects diagnosed with periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of iPRF into periodontal pockets, while in the control group SRP was performed alone. Clinical examination was performed before and 1, 3 and 6 months after treatment. For inflammation mediators levels determination in GCF samples ELISA method will be used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SRP | Experimental | In the control group (20 subjects) SRP was performed alone. |
|
| SRP+iPRF | Experimental | The test group consisted of 20 people participants who underwent the SRP procedure and then i-PRF was administered into the pockets. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SRP+iPRF | Biological | SRP (scaling and root planing) with iPRF (injectable platelet-rich fibrin) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of the influence of injectable platelet-rich fibrin on the clinical parameters in non-surgical treatment of periodontitis. | PD (Pocket Depth) from the gingival margin to the bottom of the sulcus, measured in mm | up to 6 months after treatment procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of the influence of injectable platelet-rich fibrin on the levels of inflammation mediators in the GCF in non-surgical treatment of periodontitis. | Inflammation mediators level in GCF will be determined by the immunoenzymatic method ELISA (Enzyme - Linked Immunosorbent Assay) with the use of commercial kits. | up to 3 months after treatment procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Integrated Dentistry, Medical University of Białystok | Bialystok | 15-089 | Poland |
IPD cannot be transferred to other people due to GDPR
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The study group consisted of 20 people participants who underwent the SRP procedure (scaling and root planing) and then i-PRF was administered into the pockets. In the control group also consisting of 20 people only the SRP procedure was performed. The therapeutic procedure was performed under local anesthesia (Septanest 200, Septodont, Paris, France), using an ultrasonic device (EMS Piezon, Tip PS, EMS, Nyon, Switzerland) and hand instruments (Gracey currettes (SMS), Hu-Friedy, Chicago, IL, USA) by one operator.
In the test group, i-PRF was prepared using a dedicated device (PRF Duo Quattro Centrifuge, Choukroun Pro-cess For PRF, Nice, France). After the SRP procedure, allocation was performed according to a randomization table prepared by a statistician, and i-PRF was administered into the pockets by one, trained operator.
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| SRP | Procedure | SRP (scaling and root planing) |
|
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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