Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate

Evaluation of the Role of the Plasma-rich Growth Factor (PRGF) with Primary Cleft Palate Repair Versus Primary Cleft Palate Repair in Post-operative Wound Healing and Oronasal Fistula Occurrence, a Randomized Clinical Trial

Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?

The primary objective is to assess and evaluate the improvement of wound healing (edema at 5th day post operatively) as a primary outcome, and secondary objective is to assess and evaluate the wound closure and the decreasing of the occurrence of the oronasal fistula as a secondary outcome among children with cleft palate, using plasma rich growth factor between nasal mucosa and palatal mucosa

Inclusion Criteria:

• systemically healthy patients (American Society of Anesthesiologists -ASA I and II); not older than 6-18 months
• Patients with primary non-syndromic isolated cleft palate
• Apprehensive to be in the study.

Exclusion Criteria:

• Patients with recurrent palatal fistula
• Existence of syndromic cleft palate
• Blood diseases and platelet disorders (hematological disease)
• Systematic disease radiotherapy or chemotherapy for malignancy